The Lab

The Bruce Lab at the University of Washington is focused on development and application of advanced mass spectrometry technology for biological, biophysical and biochemical studies. We specialize in Fourier transform ion cyclotron resonance mass spectrometry for proteomics, biological and biomedical applications.

RL7_ECOLI homodimeric cross-link identified using Protein Interaction Reporter (PIR) technology.

Our Research

Our group focus is in biological mass spectrometry and proteomics research. Mass Spectrometry is currently changing the way that global or systems-level research on biological organisms is carried out. Mass spectrometry has enabled the field of proteomics to arise and provide a comprehensive view of all proteins present in a biological system under a given set of conditions. Our research centers on development and application of cutting-edge mass spectrometry for advanced proteomics research.

We are developing new methods and instrumentation that allow improved application of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS) including custom ionization sources and transmission optics for increased sensitivity, new ion detection strategies that further improve mass resolution, accuracy and sensitivity. We are also developing new chemical strategies to target protein posttranslational modifications and protein-protein interactions. This combination of chemistry, biology and ion physics research is currently providing new information that enables a greater understanding in areas such as bioremediation, obesity, diabetes, cancer, and Alzheimer's disease.